Articles & Insights

Professionals Rare Diseases

When to Suspect VEXAS Syndrome: A Practical Guide for Clinicians

Since its discovery in 2020, VEXAS syndrome has rapidly emerged as an important cause of late-onset systemic inflammation associated with clonal hematopoiesis. The syndrome is increasingly recognised in patients previously labelled as having refractory autoimmune disease, relapsing polychondritis, or unexplained inflammatory syndromes with cytopenias.

Ivo Andrejco · 10 Mar 2026

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Patients Rare Diseases

When Inflammation Doesn’t Fit the Pattern: A Patient With Possible VEXAS Syndrome

Sometimes medicine follows predictable patterns. Other times it doesn’t. Recently I saw a patient whose symptoms did not neatly fit into any familiar diagnosis. He had been unwell for several years, seeing multiple specialists, undergoing many tests, and receiving different treatments — yet no single explanation tied everything together.

Ivo Andrejco · 10 Mar 2026

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