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Raised light chains

Serum free light chains are used to assess for clonally-restricted plasma cell populations. As such, they are only diagnostically useful and reflect possible pathological plasma cell conditions when there are elevated kappa or lambda serum free light chains AND the ratio of kappa to lambda free light chains is abnormal.

Ivo Andrejco · 1 Mar 2026
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Professionals

Polyclonal and oligoclonal hypergammaglobulinemia

Hypergammaglobulinemia results from an overproduction of immunoglobulins. This process may be polyclonal or oligoclonal (i.e. increased synthesis from multiple plasma cell lines as seen in infection); or monoclonal (increased synthesis from a single plasma cell clone).

Ivo Andrejco · 1 Mar 2026
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