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Patients

Monoclonal gammopathy of uncertain significance (MGUS)

Monoclonal gammopathy of undetermined significance (MGUS) happens when abnormal white blood cells make abnormal proteins called M proteins. M proteins don’t usually cause issues. Most people with MGUS don’t have symptoms. But a small percentage of people with this condition may develop blood cancer or a more serious blood disorder.

Ivo Andrejco · 1 Mar 2026
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Professionals

Raised light chains

Serum free light chains are used to assess for clonally-restricted plasma cell populations. As such, they are only diagnostically useful and reflect possible pathological plasma cell conditions when there are elevated kappa or lambda serum free light chains AND the ratio of kappa to lambda free light chains is abnormal.

Ivo Andrejco · 1 Mar 2026
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Professionals

Polyclonal and oligoclonal hypergammaglobulinemia

Hypergammaglobulinemia results from an overproduction of immunoglobulins. This process may be polyclonal or oligoclonal (i.e. increased synthesis from multiple plasma cell lines as seen in infection); or monoclonal (increased synthesis from a single plasma cell clone).

Ivo Andrejco · 1 Mar 2026
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