Lymphopenia
Last updated Nov. 3, 2025, 2:47 a.m. by ivo
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Lymphopenia
The lymphocyte reference range will vary depending on the age, gender and pregnancy status of the
patient, as well as the laboratory performing the test.
In general, the lymphocyte count is considered low when it is < 1.0 x109/L.
Lymphopenia is a common finding and an isolated longstanding lymphopenia in adult patients, outside of intercurrent illness and without evidence of recent or active infection, is unlikely to be of clinical
significance.
Common causes in adults
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Infection – HIV, hepatitis, influenza, tuberculosis
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Medications – e.g. corticosteroids, methotrexate, azathioprine, rituximab
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Autoimmune disease such as rheumatoid arthritis and SLE
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Inflammatory bowel disease
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Renal failure
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Cardiac failure
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Malnutrition
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Alcohol use
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Surgery
See also: Investigating an incidental finding of lymphopenia, BMJ 2014;348:g1721
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