Articles
Polyclonal and oligoclonal hypergammaglobulinemia
Tags: Hypergammaglobulinemia
Hypergammaglobulinemia results from an overproduction of immunoglobulins. This process may be polyclonal or oligoclonal (i.e. increased synthesis from multiple plasma cell lines as seen in infection); or monoclonal (increased synthesis from a single plasma cell clone).
Raised light chains
Tags: Amyloidosis , MGUS , Myeloma , Raised light chains
Serum free light chains are used to assess for clonally-restricted plasma cell populations. As such, they are only diagnostically useful and reflect possible pathological plasma cell conditions when there are elevated kappa or lambda serum free light chains AND the ratio of kappa to lambda free light chains is abnormal.
Neutrophilia
Tags: Neutrophilia
The neutrophil reference range will vary depending on the age, gender and pregnancy status of the patient, as well as the laboratory performing the test. In general, the neutrophil count is considered elevated when it is above 8 x 109/L.
Monocytosis
Tags: monocytosis
The monocyte reference range will vary depending on the age, gender and pregnancy status of the patient, as well as the laboratory performing the test. In general, the monocyte count is considered elevated when it is > 1 x 109/L.
Mild Anaemia
Tags: Anaemia
The haemoglobin reference range will vary depending on the age, gender and pregnancy status of the patient, as well as the laboratory performing the test. In general, the haemoglobin is considered to be low when it is < 130 g/L in males and <115 g/L in females. The MCV and reticulocyte count are useful to guide further investigation as below.