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Monoclonal gammopathy of uncertain significance (MGUS)

Monoclonal gammopathy of undetermined significance (MGUS) happens when abnormal white blood cells make abnormal proteins called M proteins. M proteins don’t usually cause issues. Most people with MGUS don’t have symptoms. But a small percentage of people with this condition may develop blood cancer or a more serious blood disorder.

Ivo Andrejco · 1 Mar 2026
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